Phosphorylation of p53 on a serine residue in the N-terminus by ATM or DNA-PK displaces bound MDM2 from p53, thereby stabilizing it

TLS Online TPP Program

#Id: 5034

#Unit 3. Fundamental Processes

Each haploid bacterium typically has a single chromosome, so this type of replication control is called single copy.

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#Id: 5035

#Unit 3. Fundamental Processes

The replicon model proposed two components that controlled the initiation of replication: the replicator and the initiator. The replicator is defined as the cis-acting DNA sequences that are sufficient to direct the initiation of DNA replication.

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#Id: 5036

#Unit 3. Fundamental Processes

The second component of the replicon model is the initiator protein.

This protein specifically recognizes a DNA element in the replicator and activates the initiation of replication

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#Id: 5037

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 5038

#Unit 3. Fundamental Processes

AT base pairs called the DNA unwinding element (DUE).

IHF (integration host factor) and FIS (factor for inversion stimulation). These two proteins were discovered as required components of certain recombination reactions.

Another DNA-binding protein, HU (a histone like bacterial protein originally dubbed factor U), also participates but does not have a specific binding site.

TLS Online TPP Program

#Id: 5039

#Unit 3. Fundamental Processes