Nurturing Life Sciences
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#Unit 2. Cellular Organization
Mutations occur at the same rate in both exons and introns, but exon mutations are eliminated more effectively by selection.
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Introns may more freely accumulate point substitutions and other changes due to no selection pressure.
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Introns evolve or accumulate mutations/changes much more rapidly than exons
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Intron do not face selective pressure to produce a polypeptide with a useful sequence hence highly variable.
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Exon sequences are conserved by the negative selection of individuals in which the sequences have changed
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Most intron mutations are expected to be selectively neutral except branch site, splicing junctions, and sequences influencing splicing