The α subunit of each integrin is the primary determinant of its extracellular ligand specificity.

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#Id: 1940

#Unit 4. Cell Communication and Cell Signaling

Regulation of complement activity

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#Id: 1941

#Unit 4. Cell Communication and Cell Signaling

Microbial Complement Evasion strategies

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#Id: 7470

#Unit 4. Cell Communication and Cell Signaling

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#Id: 7471

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 7472

#Unit 4. Cell Communication and Cell Signaling

The two β pleated sheets in each domain are held together by hydrophobic interactions and the conserved disulfide bond.  The three loops of each variable domain show considerable variation in length and amino acid sequence; these hyper variable regions  make up the antigen-binding site. 

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#Id: 7473

#Unit 4. Cell Communication and Cell Signaling

Hyper variable regions are usually called complementarity determining regions (CDRs).