The α subunit of each integrin is the primary determinant of its extracellular ligand specificity.

TLS Online TPP Program

#Id: 9680

#Unit 4. Cell Communication and Cell Signaling

A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanines is constitutively active

TLS Online TPP Program

#Id: 9681

#Unit 4. Cell Communication and Cell Signaling

PI-3 kinase signaling pathway is terminated by

PTEN phosphatase, which hydrolyzes the 3-phosphate

in PI 3-phosphates.

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#Id: 9682

#Unit 4. Cell Communication and Cell Signaling

PTEN can remove phosphate groups attached to serine,

threonine, and tyrosine residues in proteins, its ability to

remove the 3-phosphate from PI(3,4,5)P3 is its major function in cells.

TLS Online TPP Program

#Id: 9683

#Unit 4. Cell Communication and Cell Signaling

Loss of the PTEN protein contributes to the uncontrolled growth of cells.

TLS Online TPP Program

#Id: 9684

#Unit 4. Cell Communication and Cell Signaling

Insulin receptor leads to the activation of PKB

TLS Online TPP Program

#Id: 9685

#Unit 4. Cell Communication and Cell Signaling

Main action of the PKB signaling pathway

An increase in uptake of glucose from the blood within minutes.