Integrins typically exhibit low affinities for their ligands, with dissociation constants (Kd) between 10−6 and 10−7 mol/L.

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#Unit 4. Cell Communication and Cell Signaling

In the absence of Delta, 

TM subunit of Notch on the surface of a responding cell is non-covalently associated with its extracellular subunit; extracellular domain is folded

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#Id: 10047

#Unit 4. Cell Communication and Cell Signaling

Folded extracellular domain cannot

be cleaved by the cell-surface ADAM 10.

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#Unit 4. Cell Communication and Cell Signaling

ADAM 10 is a matrix metalloprotease, a member

of a class of metal-containing enzymes that cleave the

extracellular segments of target proteins.

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#Unit 4. Cell Communication and Cell Signaling

ADAM is an abbreviation for a disintegrin and

Metalloprotease (disintegrin is a conserved protein domain that binds integrins and disrupts cell-matrix interactions)

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Binding of Notch to Delta 

is followed by endocytosis of Delta by the signaling cell

TLS Online TPP Program

#Id: 10051

#Unit 4. Cell Communication and Cell Signaling

The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain