Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.

  

TLS Online TPP Program

#Id: 8195

#Unit 2. Cellular Organization

A Pex 2, Pex 10, and Pex 12 complex embedded in the peroxisomal membrane transfers Ubiquitin to two embedded Pex 5 receptors.

TLS Online TPP Program

#Id: 737

#Unit 3. Fundamental Processes

A two-state assembly model explains melting of 13mer during initiation

TLS Online TPP Program

#Id: 2451

#Unit 3. Fundamental Processes

Allolactose binds to the Lac repressor and triggers a change in the shape (conformation) of that protein. 

TLS Online TPP Program

#Id: 763

#Unit 3. Fundamental Processes

The transition from the closed to the open complex involves “melting” between positions –11 and +2, with respect to the transcription start site.

TLS Online TPP Program

#Id: 7373

#Unit 5. Developmental Biology

At the same time, the protein products of the gap, pair-rule, and segment polarity genes interact to regulate another class of genes, the homeotic selector genes, whose transcription determines the developmental fate of each segment