PMZ = Amphibian Nieuwkoop center

TLS Online TPP Program

#Id: 4758

#Unit 5. Developmental Biology

skn-1-deficient embryos make extra hypodermal (skin) & body wall tissue.

TLS Online TPP Program

#Id: 4759

#Unit 5. Developmental Biology

PAL-1 activity is needed for the normal development of the somatic (but not the germline) descendants of the P2 blastomere, specifies muscle production.

TLS Online TPP Program

#Id: 4760

#Unit 5. Developmental Biology

Embryos lacking PAL-1 have no somatic cell types derived from the C and D stem cells.

TLS Online TPP Program

#Id: 4761

#Unit 5. Developmental Biology

PAL-1 is regulated by the MEX-3 protein, an RNA binding protein that inhibit the translation of pal-1 mRNA.

TLS Online TPP Program

#Id: 4762

#Unit 5. Developmental Biology

In mex-3-deficient mutants, PAL-1 is seen in every blastomere.

TLS Online TPP Program

#Id: 4763

#Unit 5. Developmental Biology

SKN-1 also inhibits PAL-1 (preventing it from becoming active in the EMS cell).