Matrix-associated regions (MARs) may be identified by characterizing the DNA retained by the matrix isolated in vivo (left) or by identifying the fragments that can bind to the matrix from which all DNA has been removed (right).

TLS Online TPP Program

#Id: 1133

#Unit 2. Cellular Organization

CDK- Cyclin in Metazoans-

G1 Phase- cyclin D–CDK4/6

G1/S Phase- cyclin E–CDK2

S Phase- cyclin A–CDK2

M Phase- cyclin A/B–CDK1

TLS Online TPP Program

#Id: 1134

#Unit 2. Cellular Organization

CDK- Cyclin in Yeast-

G1 cyclin gene - CLN3

G1/S phase cyclin genes - CLN1 and CLN2

TLS Online TPP Program

#Id: 1135

#Unit 2. Cellular Organization

Kinase in cell cycle-

CAK kinase- Activate CDKs

Wee1 kinase- Inhibit CDKs

TLS Online TPP Program

#Id: 1136

#Unit 2. Cellular Organization

Phosphatase in cell cycle-

Cdc25 phosphatase Activates CDKs

Cdc14 phosphatase Activates Cdh1 to degrade mitotic cyclins

TLS Online TPP Program

#Id: 1137

#Unit 2. Cellular Organization

Phosphatase in cell cycle-

Cdc25A phosphatase Activates vertebrate S phase CDKs

Cdc25C phosphatase Activates vertebrate mitotic CDKs

TLS Online TPP Program

#Id: 1138

#Unit 2. Cellular Organization

Inhibitory Proteins in Cell Cycle-

Sic1 - Binds and inhibits S phase CDKs

CKIs p27, p57, and p21- Bind and inhibit CDKs

INK4 - Binds and inhibits G1 CDKs

Rb - Binds E2Fs