In most cases each TLR dimerizes with itself, forming a homodimer, but TLR2 forms heterodimers by pairing with either TLR1 or TLR6.

TLS Online TPP Program

#Id: 1349

#Unit 4. Cell Communication and Cell Signaling

RAF (also known as MAPKKK),  A ser/thr protein kinase

TLS Online TPP Program

#Id: 1350

#Unit 4. Cell Communication and Cell Signaling

KSR (Kinase suppressor of Ras) is a pseudogene homolog of RAF Involve in the activation of RAF

TLS Online TPP Program

#Id: 1351

#Unit 4. Cell Communication and Cell Signaling

CNK serves as a molecular scaffold platform for KSR-mediated RAF activation

 

TLS Online TPP Program

#Id: 1352

#Unit 4. Cell Communication and Cell Signaling

GRB2 SH3 domains bind to proline-rich sequences in Sos

  

TLS Online TPP Program

#Id: 1353

#Unit 4. Cell Communication and Cell Signaling

GRB2 SH2 domain binds to a specific phosphotyrosine residue in the cytosolic domain of an activated RTK.

 

TLS Online TPP Program

#Id: 1354

#Unit 4. Cell Communication and Cell Signaling

The SH2 domain binds strongly to any peptide containing a critical four-residue core sequence:  phosphotyrosine–glutamic acid–glutamic acid–isoleucine