Clinical trials

Phase I clinical trials assess human safety; a small number of volunteers are monitored closely for adverse side effects.

TLS Online TPP Program

#Id: 2392

#Unit 3. Fundamental Processes

Trans-splicing is rare in multicellular eukaryotes, it occurs as the primary mechanism to process precursor RNA into mature, translatable mRNAs in some organisms, such as trypanosomes and nematodes.

TLS Online TPP Program

#Id: 2393

#Unit 3. Fundamental Processes

The SL RNA provides an exon that is connected to the first exon of an mRNA by trans-splicing. The reaction involves the same interactions as nuclear cis splicing but generates a Y-shaped RNA instead of a lariat.

TLS Online TPP Program

#Id: 2394

#Unit 3. Fundamental Processes

In C. elegans, about 70% of genes are processed by the trans-splicing mechanism

TLS Online TPP Program

#Id: 2395

#Unit 3. Fundamental Processes

The introns in pre-tRNA vary in length from 14 to 60 bases and only single intron is found in each pre-tRNA transcript

TLS Online TPP Program

#Id: 2396

#Unit 3. Fundamental Processes

Single intron that is located just one nucleotide beyond the 3’ side of the anticodon

TLS Online TPP Program

#Id: 2397

#Unit 3. Fundamental Processes

Splicing of pre-tRNAs is catalyzed by proteins, not by RNAs.