TLS Online TPP Program

#Id: 2451

#Unit 3. Fundamental Processes

Allolactose binds to the Lac repressor and triggers a change in the shape (conformation) of that protein. 

TLS Online TPP Program

#Id: 2452

#Unit 3. Fundamental Processes

In the absence of allolactose, the repressor is present in a form that binds its site on DNA (and so keeps the lac genes switched off ). 

TLS Online TPP Program

#Id: 2453

#Unit 3. Fundamental Processes

Allolactose binds to a part of the Lac repressor distinct from its DNA-binding domain.

TLS Online TPP Program

#Id: 2454

#Unit 3. Fundamental Processes

Negative control of the lac operon. 

No lactose; repression. The lacI gene produces repressor, which binds to the operator and blocks RNA polymerase from transcribing the lac genes.

TLS Online TPP Program

#Id: 2455

#Unit 3. Fundamental Processes

Binding of the repressor to the operator sequence blocks binding of RNA polymerase and so inhibits transcription.

TLS Online TPP Program

#Id: 6654

#Unit 3. Fundamental Processes