The b subunit of RNA polymerase is implicated by two types of mutation. 

First, mutations in the rpoB gene can reduce termination at a rho-dependent site. 

Second, mutations in rpoB can restore the ability to terminate transcription at rho-dependent sites in rho mutant bacteria.

TLS Online TPP Program

#Id: 10506

#Unit 4. Cell Communication and Cell Signaling

Human Bcl-2 and worm CED-9 both proteins contain a single TM domain and are localized to the outer mitochondrial membrane

TLS Online TPP Program

#Id: 10507

#Unit 4. Cell Communication and Cell Signaling

CED-9 protein, forms a complex with a dimer of the CED-4 protein, preventing the CED-4 protein from activating the CED-3 protease

TLS Online TPP Program

#Id: 10508

#Unit 4. Cell Communication and Cell Signaling

CED-4 is a protease-activating factor that causes autoproteolytic cleavage of the CED-3 protease to promote its activation and to initiate cell death

TLS Online TPP Program

#Id: 10509

#Unit 4. Cell Communication and Cell Signaling

CED-4 in C. elegans = Apaf-1 in Mammals

TLS Online TPP Program

#Id: 10510

#Unit 4. Cell Communication and Cell Signaling

The principal caspase in C. elegans is CED-3

TLS Online TPP Program

#Id: 10511

#Unit 4. Cell Communication and Cell Signaling

CED-3 in C. elegans = Caspase-9 in mammals