Nurturing Life Sciences
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#Unit 2. Cellular Organization
Filament capping proteins:
CapZ blocks (+)end Tropomodulin blocks (-)end
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Two major classes of actin-nucleating proteins:
1. Formins nucleate the assembly of unbranched filaments
2. Arp2/3 complex nucleates the assembly of branched actin networks
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formin family members have two adjacent domains:
FH1- rich in proline, landing site for profilin–ATP–G-actin
FH2 - form a dimer and nucleate filament assembly
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