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TLS Online TPP Program

#Id: 3219

Transcribed genes are preferentially repaired when DNA damage occurs.

#Unit 3. Fundamental Processes #DNA damage and repair mechanisms #Part B Pointers
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TLS Online TPP Program

#Id: 1375

#Unit 4. Cell Communication and Cell Signaling

STAT5 becomes activated in erythroid progenitor cells,  induces expression of the protein Bcl-xL.
TLS Online TPP Program

#Id: 1376

#Unit 4. Cell Communication and Cell Signaling

Two mechanisms for terminating cytokine signal transduction
1.  Short-term regulation
2.  Long-term regulation
TLS Online TPP Program

#Id: 1377

#Unit 4. Cell Communication and Cell Signaling

Short-term regulation: 
JAK2 deactivation by SHP1 phosphatase
TLS Online TPP Program

#Id: 1378

#Unit 4. Cell Communication and Cell Signaling

Long-term regulation: 
• SOCS proteins
• Targets the receptor as well as JAK2 for degradation by the ubiquitin-proteasome pathway
TLS Online TPP Program

#Id: 1379

#Unit 4. Cell Communication and Cell Signaling

The rate-limiting step in actin filament assembly is the formation of a short actin oligomer (nucleus).
TLS Online TPP Program

#Id: 1380

#Unit 4. Cell Communication and Cell Signaling

The critical concentration (Cc) is the concentration of free G-actin at which the filaments are formed.