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TLS Online TPP Program

#Id: 8129

Some other biologically active isoprenoid compounds or derivatives.

#Unit 1. Molecules and their Interaction Relevant to Biology #Lipid #Part B Pointers
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TLS Online TPP Program

#Id: 8925

#Unit 2. Cellular Organization

The protein kinases DNA-PK, ATM, and ATR are activated at sites of damaged DNA
TLS Online TPP Program

#Id: 8926

#Unit 2. Cellular Organization

ATR activated by single-stranded DNA breaks.
TLS Online TPP Program

#Id: 8927

#Unit 2. Cellular Organization

ATM and DNA-PK are specifically activated by double-strand breaks
TLS Online TPP Program

#Id: 8928

#Unit 2. Cellular Organization

ATM and ATR, activate a triad of related protein kinases: Chk1, Chk2, and MK2
TLS Online TPP Program

#Id: 8929

#Unit 2. Cellular Organization

Chk1, Chk2, and MK2
cause cell cycle arrest by inhibiting Cdc25
stabilizing the transcription factor p53, which induces the transcription of CKI p21 
TLS Online TPP Program

#Id: 8930

#Unit 2. Cellular Organization

If the DNA damage is severe, p21 can cause the cells to senesce or p53 can induce apoptosis.