In addition to proteins involved in NER, a variant form of XP called XP-V is caused by a defect in the translesion DNA polymerase, Pol h. The gene encoding Pol h is sometimes called XPV. Individuals with XP-V have a milder form of XP.

TLS Online TPP Program

#Id: 504

#Unit 2. Cellular Organization

Drosophila melanogaster also shows C-value paradox in term of their number of genes.

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#Id: 7204

#Unit 5. Developmental Biology

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#Id: 6865

#Unit 3. Fundamental Processes

E(var) mutations lie in genes whose products are needed to activate gene expression. They include members of the SWI/SNF complex

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#Id: 10262

#Unit 6. System Physiology – Plant

Dehydration triggers de novo production of ABA, which in turn induces expression of stress‐related genes

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#Id: 3982

#Unit 2. Cellular Organization

Camptothecin is an inhibitor of eukaryotic type I topoisomerases.

Irinotecan (Campto) and topotecan (Hycamtin)—used to treat colorectal cancer and ovarian cancer.

All these drug's act by trapping the topoisomerase-DNA complex in which the DNA is cleaved, inhibiting religation.