Together, the two H2A.H2B dimers form the bottom part of the histone octamer located across the disc from the DNA ends

TLS Online TPP Program

#Id: 10472

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10473

#Unit 4. Cell Communication and Cell Signaling

Deletion that causes loss of the extracellular ligand-binding domain in the EGF receptor leads, to

constitutive activation of the kinase activity of the resulting oncoprotein, ErbB.

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#Unit 4. Cell Communication and Cell Signaling

A point mutation substitutes any other amino acid

for the glycine12 in the Ras, the normal protein is converted into a constitutively active oncoprotein

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#Id: 10475

#Unit 4. Cell Communication and Cell Signaling

Ras-GAP protein, 

NF1 (neurofibromatosis)

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#Id: 10476

#Unit 4. Cell Communication and Cell Signaling

Inherited a single mutant NF1 allele then develop neurofibromas, a benign tumor of the sheath cells that surround nerves, caused by loss of both alleles through LOH.

TLS Online TPP Program

#Id: 10477

#Unit 4. Cell Communication and Cell Signaling

In certain tumors of antibody-producing B lymphocytes, the cyclin D1 gene is translocated & its transcription is

under the control of an antibody-gene enhancer, causing elevated cyclin D1 production.