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TLS Online TPP Program

#Id: 398


Modification of histones is associated with replication and transcription, and specific modifications also facilitate DNA repair.

#Unit 2. Cellular Organization #Histone Variants #Part B Pointers
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TLS Online TPP Program

#Id: 6790

#Unit 3. Fundamental Processes

The miRNAs used in RNAi are produced as large RNA primary transcripts called pri-miRNA that are self-complementary and can automatically fold into a double-strand hairpin structure.


TLS Online TPP Program

#Id: 6791

#Unit 3. Fundamental Processes

pri-miRNA is processed in a two-step reaction
The first step is catalyzed by Drosha, an RNase III superfamily member endonuclease, in the nucleus. Drosha reduces the pri-RNA to about a 70-bp, hairpin-shaped precursor fragment, pre-miRNA



TLS Online TPP Program

#Id: 6792

#Unit 3. Fundamental Processes


TLS Online TPP Program

#Id: 6793

#Unit 3. Fundamental Processes

The two cleavages thus generate the 65-nucleotide pre-miRNA composed of the 22 bp (two helical turns) of dsRNA and the top loop.


TLS Online TPP Program

#Id: 6794

#Unit 3. Fundamental Processes


TLS Online TPP Program

#Id: 6795

#Unit 3. Fundamental Processes

First cleavage reaction in nucleus leaves a 2-nucleotide overhang on the 3’ ends of the dsRNA product. This 3’ overhang is important for recognition of that RNA molecule by the next enzyme in the cytosolic pathway, Dicer.


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