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TLS Online TPP Program

#Id: 4049

This is used to identify when regulatory proteins bound at an enhancer are in close proximity to the transcriptional machinery at a given promoter—a physical proximity interpreted to show looping out of the DNA

#Unit 2. Cellular Organization #Structure of chromatin and chromosomes #Part B Pointers
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TLS Online TPP Program

#Id: 490

#Unit 2. Cellular Organization

S/MARs is a DNA sequence which binds to base structure called scaffold.
TLS Online TPP Program

#Id: 491

#Unit 2. Cellular Organization

If histones are depleted from a metaphase chromosome and viewed under a transmission electron microscope shows SCAFFOLD.
TLS Online TPP Program

#Id: 492

#Unit 2. Cellular Organization

The metaphase scaffold consists of a dense network of fibers. Threads of DNA emanate from the scaffold, apparently as loops of average length 30 to 90 kb.
TLS Online TPP Program

#Id: 493

#Unit 2. Cellular Organization

S/MARs are constitutive (continuously bound to the matrix or scaffold), or facultative and change their interactions with the matrix depending on cell type or other conditions.
TLS Online TPP Program

#Id: 494

#Unit 2. Cellular Organization

SATB1, is a protein that appears to regulate the association of MARs with the matrix in order to regulate transcription of genes in the vicinity of the MAR.
TLS Online TPP Program

#Id: 495

#Unit 2. Cellular Organization

Genome = Pool of genes or place or where gene are positioned or Chromosomes