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#Unit 12. Applied Biology #Vaccines #Part B Pointers
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#Unit 2. Cellular Organization

Detyrosylated microtubules are more stable, because they are more resistant to depolymerization by kinesin-13 and related proteins.

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#Unit 2. Cellular Organization

Polyglutamylation and polyglycylation are likely mutually exclusive, so they would not normally occur at the same time & both can enhance microtubule stability,

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#Unit 2. Cellular Organization

Kinesin-1 associates preferentially with detyrosylated and acetylated microtubules.

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#Unit 2. Cellular Organization

Polyglutamylation has a key role in the beating of cilia and flagella

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#Unit 2. Cellular Organization

Class IV IF proteins compose the neurofilaments found in neurons.

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#Unit 2. Cellular Organization

Class III IF proteins- found in cells of mesodermal origin
Desmin, GFAP, vimentin

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