S/MARs are constitutive (continuously bound to the matrix or scaffold), or facultative and change their interactions with the matrix depending on cell type or other conditions.

#Id: 2973

#Unit 3. Fundamental Processes

in mammalian cells, Cdt1 is targeted for degradation by the action of a protein complex that is recruited to the origin of replication by PCNA, the eukaryotic counterpart of the bacterial beta-clamp.

#Id: 2974

#Unit 3. Fundamental Processes

#Id: 2975

#Unit 3. Fundamental Processes

The MCM proteins, once activated, are required for elongation as well as for initiation.

#Id: 2976

#Unit 3. Fundamental Processes

The MCM proteins continue to function at the two bidirectional replication forks as the replication helicase.

#Id: 2977

#Unit 3. Fundamental Processes

In yeast, the combined action of Cdc6, Cdtl, and the MCM proteins provides the licensing function.

#Id: 2978

#Unit 3. Fundamental Processes