Before replication, the palindromic target GATC site is methylated by dam methylase on the N6 of A of each strand.

Replication generates hemimethylated DNA, in which one strand is methylated and one strand is unmethylated.

Thus, the replication event converts Dam target sites from fully methylated to hemimethylated condition.

TLS Online TPP Program

#Id: 5814

#Unit 7. System Physiology – Animal

The synthesis and secretion of steroid hormones by the adrenal cortex depend on the stimulation of cholesterol desmolase by ACTH

TLS Online TPP Program

#Id: 5815

#Unit 7. System Physiology – Animal

The zona fasciculata/reticularis, is under the exclusive control of the hypothalamic-pituitary axis.

TLS Online TPP Program

#Id: 5816

#Unit 7. System Physiology – Animal

Negative feedback  is exerted by cortisol in the hypothalamic- pituitary axis.

TLS Online TPP Program

#Id: 5817

#Unit 7. System Physiology – Animal

The zona glomerulosa is controlled via; Renin-angiotensin- aldosterone system

TLS Online TPP Program

#Id: 5818

#Unit 7. System Physiology – Animal

Aldosterone has three actions on the late distal tubule and collecting ducts of the kidney:

TLS Online TPP Program

#Id: 5819

#Unit 7. System Physiology – Animal

The renal epithelial cells express the enzyme 11β-HSD2, which prevent cortisol from activating mineralocorticoid receptors.