“Organification” of Thyroglobulin- Iodination of tyrosine and formation of the thyroid hormones

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#Unit 4. Cell Communication and Cell Signaling

Rod cells sense light with the aid of a light-sensitive GPCR called rhodopsin.

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#Id: 9300

#Unit 4. Cell Communication and Cell Signaling

Rhodopsin has two components: 

Opsin protein, member of the GPCR A family 

11-cis-retinal light-absorbing pigment

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#Id: 9301

#Unit 4. Cell Communication and Cell Signaling

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#Id: 9302

#Unit 4. Cell Communication and Cell Signaling

11-cis-retinal covalently attached to the amino group of lysine residue 296 in the opsin protein

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#Unit 4. Cell Communication and Cell Signaling

The heterotrimeric G protein coupled to rhodopsin, called transducin (Gt)

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#Id: 9304

#Unit 4. Cell Communication and Cell Signaling

In the absence of light,  bound 11-cis-retinal locks the rhodopsin into its inactive (R) conformation