In mammalian cells, Cdc6 is controlled differently; it is phosphorylated during S phase, and as a result it is degraded by the ubiquitination pathway. Cdt1 is initially stabilized by the protein Geminin, which prevents its degradation, and subsequent Geminin binding prevents its reuse
#Unit 3. Fundamental Processes#Eukaryotic DNA Replication#Part B Pointers
