#Id: 6149
Ku70, Ku80, DNA-PKcs, Artemis, XRCC4, Cernunnos-XLF, and DNA ligase IV. Ku70 and Ku80 are the most fundamental components of NHEJ.
They constitute a heterodimer that binds to the DNA ends and recruits DNA-PKcs, which is a protein kinase. DNA-PKcs, in turn, forms a complex with Artemis. Artemis is both a 5’-to-3’ exonuclease and a latent endonuclease that is activated by phosphorylation by DNA-PKcs.
These nucleolytic activities process the broken ends and prepare them for ligation. Ligase IV performs ligation in a complex with XRCC4 and Cernunnos-XLF.
#Unit 3. Fundamental Processes
#Mutation and Repair
#Part B Pointers
