ANDROGEN-INSENSITIVITY SYNDROME

These individuals have female external sexual characteristics. Vagina ends blindly and that the uterus, oviducts, and ovaries are absent.

 Inside the abdominal cavity, a pair of testes produce levels of testosterone normally seen in males. 

Woman with androgen-insensitivity syndrome contain an X and a Y chromosome. 

Testosterone bind to an androgen receptor. This receptor is defective in females with androgen-insensitivity syndrome.

The gene for the androgen receptor is located on the X chromosome

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#Unit 3. Fundamental Processes

1. The length of the transcription bubble is 12 to 14 bp, but the length of the RNA–DNA hybrid within the bubble is only 8 to 9 bp. 

2. As the enzyme moves along the template, the DNA duplex reforms, and the RNA is displaced as a free polynucleotide chain. 

3. The last 14 ribonucleotides in the growing RNA are complexed with the DNA and/or the enzyme at any given moment.

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#Unit 3. Fundamental Processes

Mechanism: How Polymerase Find Promoter Sequences

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#Unit 3. Fundamental Processes

Amino acids in the 2.4 a-helix of beta70 contact specific bases in the coding strand of the -10 promoter sequences.

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#Unit 3. Fundamental Processes

Initiation complex contains sigma and covers 75bp

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#Unit 3. Fundamental Processes

Initiation elongation complex forms at 10 bases, mayloses sigma, and loses contacts from -35 to -55.

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#Unit 3. Fundamental Processes