Hemophilia  

X-Linked recessive disease

Reduces blood clotting

TLS Online TPP Program

#Id: 2975

#Unit 3. Fundamental Processes

The MCM proteins, once activated, are required for elongation as well as for initiation.

TLS Online TPP Program

#Id: 2976

#Unit 3. Fundamental Processes

The MCM proteins continue to function at the two bidirectional replication forks as the replication helicase.

TLS Online TPP Program

#Id: 2977

#Unit 3. Fundamental Processes

In yeast, the combined action of Cdc6, Cdtl, and the MCM proteins provides the licensing function.

TLS Online TPP Program

#Id: 2978

#Unit 3. Fundamental Processes

This alteration to the structure of the chromosome is accomplished by the enzyme topoisomerase. Replication cannot occur on supercoiled DNA, only the relaxed form.

TLS Online TPP Program

#Id: 2979

#Unit 3. Fundamental Processes

The replisome exists only as a protein complex associated with the particular structure that DNA takes at the replication fork.

TLS Online TPP Program

#Id: 2980

#Unit 3. Fundamental Processes

It does not exist as an independent unit (e.g., analogous to the ribosome), but assembles de novo at the origin for each replication cycle.