Glucagon secretion is increased by stimulation of the sympathetic nerves to the pancreas, & sympathetic effect is mediated via β-adrenergic receptors and cAMP

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#Id: 6555

#Unit 7. System Physiology – Animal

Type 2 diabetes (non-insulin-dependent diabetes mellitus) is characterized by the dysregulation of insulin release from the B cells, along with insulin resistance in peripheral tissues such as skeletal muscle, brain, and liver

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#Id: 6556

#Unit 7. System Physiology – Animal

Glucagon Secretion is increased by hypoglycaemia and decreased by a rise in plasma glucose

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#Id: 6557

#Unit 7. System Physiology – Animal

Human preproglucagon is a 179-amino-acid protein that is found in pancreatic A cells, in L cells in the lower GIT, and in the brain

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#Id: 6558

#Unit 7. System Physiology – Animal

In A cells, preproglucagon is processed primarily to glucagon and major proglucagon fragment (MPGF)

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#Id: 6559

#Unit 7. System Physiology – Animal

In L cells, preproglucagon is processed primarily to glicentin, & glucagon-like polypeptides 1 and 2. Some oxyntomodulin is also formed

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#Id: 6560

#Unit 7. System Physiology – Animal

In both A and L cells, residual glicentin-related polypeptide (GRPP) is left