Trans-splicing is rare in multicellular eukaryotes, it occurs as the primary mechanism to process precursor RNA into mature, translatable mRNAs in some organisms, such as trypanosomes and nematodes.

TLS Online TPP Program

#Id: 1496

#Unit 4. Cell Communication and Cell Signaling

p19ARF protein in the Mouse = p14ARF in Humans

TLS Online TPP Program

#Id: 1497

#Unit 4. Cell Communication and Cell Signaling

P53 turned on GADD45 to stimulate DNA repair.

TLS Online TPP Program

#Id: 1498

#Unit 4. Cell Communication and Cell Signaling

P53 turned on  p2I/WAF-I, which binds to and inhibits the CDK/cyclin complexes for GI arrest

TLS Online TPP Program

#Id: 1499

#Unit 4. Cell Communication and Cell Signaling

P53 turned on sets of large intergenic noncoding RNAs to mediate transcription repression; and miRNAs.

TLS Online TPP Program

#Id: 1500

#Unit 4. Cell Communication and Cell Signaling

p2I -IincRNA, mediates the repressive properties of p53 by binding to specific chromatin complexes.

TLS Online TPP Program

#Id: 1501

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 lose its suppressor function and acquire oncogenic function.