The exposed cap is then removed by a decapping enzyme (DCP1/DCP2), unprotected mRNA susceptible to degradation by XRN1, a 5′→3′ exoribonuclease. Removal of the poly(A) tail also makes mRNAs susceptible to degradation by cytoplasmic exosomes containing 3′→5′ exonucleases.

TLS Online TPP Program

#Id: 815

#Unit 3. Fundamental Processes

Sigma inhibits non specific binding of holoenzyme so fourth slides rapidly over non promoters sequences but binding strongly to promoters

TLS Online TPP Program

#Id: 5029

#Unit 3. Fundamental Processes

A cycle of chromosome replication must be initiated at a fixed time of C + D =60 minutes before cell division.

TLS Online TPP Program

#Id: 2934

#Unit 3. Fundamental Processes

oriC is hemimethylated and remains in that condition for approximately 13 minutes.

TLS Online TPP Program

#Id: 3209

#Unit 4. Cell Communication and Cell Signaling

Dominant gain-of-function mutations in proto-oncogenes and recessive loss-of-function mutations in tumor-suppressor genes are oncogenic.

TLS Online TPP Program

#Id: 7377

#Unit 5. Developmental Biology

Bicoid mRNA binds to dynein, a “minus-directed” motor protein associated with the nongrowing end of microtubules; dynein moves the bicoid mRNA to the anterior end of the egg.