The DNA of the inactive X also becomes methylated at most of its CpG island promoters. Specialized histone octamers in which histone H2A is replaced by a paralog of H2A called macroH2A also become associated with the inactive X.

TLS Online TPP Program

#Id: 5815

#Unit 7. System Physiology – Animal

The zona fasciculata/reticularis, is under the exclusive control of the hypothalamic-pituitary axis.

TLS Online TPP Program

#Id: 5816

#Unit 7. System Physiology – Animal

Negative feedback  is exerted by cortisol in the hypothalamic- pituitary axis.

TLS Online TPP Program

#Id: 5817

#Unit 7. System Physiology – Animal

The zona glomerulosa is controlled via; Renin-angiotensin- aldosterone system

TLS Online TPP Program

#Id: 5818

#Unit 7. System Physiology – Animal

Aldosterone has three actions on the late distal tubule and collecting ducts of the kidney:

TLS Online TPP Program

#Id: 5819

#Unit 7. System Physiology – Animal

The renal epithelial cells express the enzyme 11β-HSD2, which prevent cortisol from activating mineralocorticoid receptors.

TLS Online TPP Program

#Id: 5820

#Unit 7. System Physiology – Animal

Apparent mineralocorticoid excess (AME)

11β-hydroxysteroid dehydrogenase type 2 is inhibited or absent