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TLS Online TPP Program

#Id: 6940

An inversion may break a gene into two parts, with one part moving to a new location and destroying the function of that gene.



#Unit 8. Inheritance Biology #Structural and numerical alterations of chromosomes #Part B Pointers
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TLS Online TPP Program

#Id: 1425

#Unit 4. Cell Communication and Cell Signaling

Several integrin α subunits contain, I-domain, which can mediate binding of integrins to various collagens in the ECM.
TLS Online TPP Program

#Id: 1426

#Unit 4. Cell Communication and Cell Signaling

I-domains also recognize CAMs on other cells,  ICAMs, VCAMs and participate in cell-cell adhesion.
TLS Online TPP Program

#Id: 1427

#Unit 4. Cell Communication and Cell Signaling

The non-I-domain α subunits recognize RGD motif.
TLS Online TPP Program

#Id: 1428

#Unit 4. Cell Communication and Cell Signaling

TGF-β1 and TGF-β3 contain RGD motif that binds to integrins.
TLS Online TPP Program

#Id: 1429

#Unit 4. Cell Communication and Cell Signaling

Integrins typically exhibit low affinities for their ligands, with dissociation constants (Kd) between 10−6 and 10−7 mol/L.
TLS Online TPP Program

#Id: 1430

#Unit 4. Cell Communication and Cell Signaling

Integrins are involved in biological activities, includes: 
Extravasation
Cell-to-cell adhesion
Cell migration
Receptors for certain viruses
Angiogenesis
Apoptosis