1. The small fragment (35 kD) possesses a 5’– 3’ exonucleolytic activity, which excises small groups of nucleotides, up to 10 bases at a time.

2. This activity is coordinated with the synthetic/ proofreading activity. 

3. It provides DNA polymerase I with a unique ability to start replication in vitro at a nick in DNA.

#Id: 1101

#Unit 2. Cellular Organization

#Id: 1102

#Unit 2. Cellular Organization

Na+/K+ ATPase generates the low cytosolic Na+ and high cytosolic K+ concentrations. 

#Id: 1103

#Unit 2. Cellular Organization

#Id: 1104

#Unit 2. Cellular Organization

Transmembrane domain with the binding sites for transported ligand.

#Id: 1105

#Unit 2. Cellular Organization

Phosphorylation domain contains the canonical Asp351 phosphorylated.

#Id: 1106

#Unit 2. Cellular Organization

Nucleotide binding domain serves as a built-in protein kinase that functions to phosphorylate the P domain.