The binding of ammonia to the sensor domain of DhkC leads to the activation of its histidine kinase activity and to the autophosphorylation of a DhkC histidine residue.

TLS Online TPP Program

#Id: 5818

#Unit 7. System Physiology – Animal

Aldosterone has three actions on the late distal tubule and collecting ducts of the kidney:

TLS Online TPP Program

#Id: 5819

#Unit 7. System Physiology – Animal

The renal epithelial cells express the enzyme 11β-HSD2, which prevent cortisol from activating mineralocorticoid receptors.

TLS Online TPP Program

#Id: 5820

#Unit 7. System Physiology – Animal

Apparent mineralocorticoid excess (AME)

11β-hydroxysteroid dehydrogenase type 2 is inhibited or absent

TLS Online TPP Program

#Id: 5821

#Unit 7. System Physiology – Animal

ACTH stimulates the synthesis and secretion of cortisol by the activation of adenylyl cyclase via Gs.

TLS Online TPP Program

#Id: 5822

#Unit 7. System Physiology – Animal

Angiotensin II stimulates the synthesis and secretion of aldosterone by the activation of phospholipase C via Gq

TLS Online TPP Program

#Id: 5823

#Unit 7. System Physiology – Animal

Important effect of cortisol, Decrease translocation of GLUT4 to the cell membrane