Loops and Turn

Small loops with regular hydrogen bond pattern and specific dihedral angles are termed as turns

TLS Online TPP Program

#Id: 2903

#Unit 3. Fundamental Processes

The four 9-bp consensus sequences on the right side of oriC provide the initial binding sites for DnaA-ATP in an extended multimeric state promoted by the accessory protein DiaA, which stimulates cooperative binding of DnaA.

TLS Online TPP Program

#Id: 2904

#Unit 3. Fundamental Processes

DnaA-ATP binds cooperatively to form a helical central core around which oriC DNA is wrapped.

TLS Online TPP Program

#Id: 2905

#Unit 3. Fundamental Processes

DnaA then acts at three A-T-rich 13 -bp tandem repeats located on the left side of oriC

TLS Online TPP Program

#Id: 2906

#Unit 3. Fundamental Processes

Two to four monomers of Dna AA TP bind at the origin, and after release of DiaA, they recruit two "pre-priming" complexes of the DnaB helicase bound to DnaC-ATP, so that there is one DnaB-DnaC-ATP complex for each of the two (bidirectional) replication forks.

TLS Online TPP Program

#Id: 2907

#Unit 3. Fundamental Processes

The function of DnaC is that of a chaperone to repress the helicase activity of DnaB until it is needed.

TLS Online TPP Program

#Id: 2908

#Unit 3. Fundamental Processes

Each DnaB-DnaC complex consists of six DnaC monomers bound to a hexamer of DnaB