VDAC 

A multifunctional transmembrane channel protein (similar in structure to bacterial porins) allow passing of  ions and most small hydrophilic molecules (up to about 5000 Da).

TLS Online TPP Program

#Id: 8271

#Unit 1. Molecules and their Interaction Relevant to Biology

Misplaced Dispersion forces are responsible for

1. Sickle-Cell Anemia

2. Alzheimer's disease

3. CFTR

4. Huntington disease

TLS Online TPP Program

#Id: 8043

#Unit 1. Molecules and their Interaction Relevant to Biology

RS Configuration 

Atoms of higher atomic number rank above those of lower atomic number (e.g., —OH ranks above —CH3). If the first substituent atoms are identical, the priority is established by the next atom outward from the chiral center (e.g., —CH2OH takes precedence over —CH3).

TLS Online TPP Program

#Id: 7075

#Unit 3. Fundamental Processes

isoleucyl-tRNA synthetase has a nearby editing pocket (a deep cleft in the enzyme) that allows it to proofread the product of the adenylylation reaction. AMP-valine (as well as adenylylates of other small amino acids, such as alanine) can fit into this editing pocket, where it is hydrolyzed and released as free valine and AMP. In contrast, AMP-isoleucine is too large to enter the editing pocket and is therefore not subject to hydrolysis. As a consequence, isoleucyl-tRNA synthetase discriminates against valine twice: in the initial binding and adenylylation of the amino acid (discriminating by a factor of 100), and then in the editing of the adenylylated amino acid (again discriminating by a factor of 100), for an

overall selectivity of 10,000-fold (i.e., an error rate of 0.01%).

TLS Online TPP Program

#Id: 10269

#Unit 6. System Physiology – Plant

Flooding enhances Ethylene entrapment and biosynthesis, followed by a decrease in ABA concentration and an increase in responsiveness to the hormone gibberellin (GA)

TLS Online TPP Program

#Id: 6968

#Unit 8. Inheritance Biology