Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 1440

#Unit 4. Cell Communication and Cell Signaling

Desmosomes

Function- Strength, durability, signaling

TLS Online TPP Program

#Id: 742

#Unit 3. Fundamental Processes

The phosphodiester bond is formed in an SN2 reaction in which the hydroxyl group at the 3’ end of the primer strand attacks the a-phosphoryl group of the incoming nucleoside triphosphate.

TLS Online TPP Program

#Id: 5780

#Unit 7. System Physiology – Animal

Thyroid gland is composed of large numbers of closed follicles & concerned with the production of thyroid hormone

TLS Online TPP Program

#Id: 7982

#Unit 10. Ecological Principles

Adaptation to water viscosity

Some small aquatic organisms exploit the high viscosity of water by evolving large appendages

Streamlined shapes that reduce the drag caused by the high viscosity of water

TLS Online TPP Program

#Id: 3687

#Unit 2. Cellular Organization

Pathogenicity islands GC content often differs from that of the rest of the genome, and it is likely that these regions are spread among bacteria by a process of horizontal transfer.