TLS Online TPP Program

#Id: 3999

#Unit 2. Cellular Organization

Interphase chromatin remain attached to nuclear wall proteins via matrix attachment regions (MARs) or matrix attachment DNA sequences.

TLS Online TPP Program

#Id: 4000

#Unit 2. Cellular Organization

(MARs) also called scaffold attachment regions (SARs), or S/MARs in case of metaphase chromosome as the same sequences appear to attach to the protein substructure in both metaphase and interphase cells.

TLS Online TPP Program

#Id: 4002

#Unit 2. Cellular Organization

If histones are depleted from a metaphase chromosome and viewed under a transmission electron microscope shows SCAFFOLD. Which is almost 8% of wt

TLS Online TPP Program

#Id: 4003

#Unit 2. Cellular Organization

Full relaxation of the supercoils requires 1 nick/85 kb, thus identifying the average length of “closed” DNA. This region could comprise a loop or domain similar in nature to those identified in the bacterial genome called as metaphase scaffold.

TLS Online TPP Program

#Id: 4004

#Unit 2. Cellular Organization

S/MARs is a DNA sequence which is generally located between H1 and H3 binding sites.

TLS Online TPP Program

#Id: 4005

#Unit 2. Cellular Organization

Radial loops in metaphase chromosomes. In the radial loop model of metaphase chromosome organization, domains of 30 kb to 100 kb emanate from a central protein scaffold that spirals through the axis of each chromosome arm..