A second NPF is a large protein complex called WAVE

and requires small GTP-binding protein Rac1.

TLS Online TPP Program

#Id: 1409

#Unit 4. Cell Communication and Cell Signaling

Thick-filament regulation Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

#Id: 1410

#Unit 4. Cell Communication and Cell Signaling

Smooth muscle cells and nonmuscle cells are regulated by: Norepinephrine, angiotensin, endothelin, histamine

TLS Online TPP Program

#Id: 1411

#Unit 4. Cell Communication and Cell Signaling

Smooth muscle contraction is regulated by the cycling of myosin II between on and off states.

     OR

Smooth muscle contraction is regulated by myosin regulatory light chain associated with the myosin II neck domain.

TLS Online TPP Program

#Id: 1412

#Unit 4. Cell Communication and Cell Signaling

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain activates contraction in Ca2+ dependent manner.

TLS Online TPP Program

#Id: 1413

#Unit 4. Cell Communication and Cell Signaling

When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 1414

#Unit 4. Cell Communication and Cell Signaling

The CaM*-Ca2+ complex binds and activates MLC kinase, phosphorylates the myosin LC.