In the presence of a non-competitive inhibitor which will bind equally well to E or to ES- Vmax decreases but not Km 

TLS Online TPP Program

#Id: 6566

#Unit 7. System Physiology – Animal

Glucagon receptors located on the same hepatic cells to activate phospholipase C, and the resulting increase in cytoplasmic Ca2+ also stimulates glycogenolysis

TLS Online TPP Program

#Id: 6567

#Unit 7. System Physiology – Animal

Pancreatic B cells contain GABA, and coincident with the increased insulin secretion produced by hyperglycemia, GABA is released and acts on the A cells by activating GABA A receptors

TLS Online TPP Program

#Id: 6568

#Unit 7. System Physiology – Animal

GABA A receptors are Cl– channels, and the resulting Cl– influx hyperpolarizes the A cells to inhibit glucagon secretion 

TLS Online TPP Program

#Id: 6569

#Unit 7. System Physiology – Animal

Glucagon secretion is increased by stimulation of the sympathetic nerves to the pancreas, & sympathetic effect is mediated via β-adrenergic receptors and cAMP

TLS Online TPP Program

#Id: 6570

#Unit 7. System Physiology – Animal

Somatostatin 14 and its amino terminal-extended form somatostatin 28 are found in the D cells of pancreatic islets

TLS Online TPP Program

#Id: 6571

#Unit 7. System Physiology – Animal

SS14 & SS28 both inhibits the secretion of insulin, glucagon, and pancreatic polypeptide and act locally within the pancreatic islets in a paracrine fashion