TLS Online TPP Program

#Id: 2940

#Unit 3. Fundamental Processes

Note that a crudal difference between replication in bacteria and replication in eukaryotes is that in bacteria replication is occurring on DNA, while in eukaryotes replication is occurring on chromatin and nucleosomes play a role so their presence must be taken into account.

TLS Online TPP Program

#Id: 2941

#Unit 3. Fundamental Processes

A eukaryotic chromosome contains multiple origins of replication that ultimately merge during replication.

TLS Online TPP Program

#Id: 2942

#Unit 3. Fundamental Processes

The rate of replication is -2000 bp/min, which is much slower than the 50,000 bp/min of bacterial replication fork movement, presumably because the chromosome is assembled into chromatin, not naked DNA.

TLS Online TPP Program

#Id: 2943

#Unit 3. Fundamental Processes

The Mammalian genome could be replicated in -1 hour if all replicons functioned simultaneously.

TLS Online TPP Program

#Id: 2944

#Unit 3. Fundamental Processes

Most chromosomal replicons do not have a termination region like that of bacteria at which the replication forks cease movement and (presumably) dissociate from the DNA. 

TLS Online TPP Program

#Id: 2945

#Unit 3. Fundamental Processes

individual replicons in eukaryotic genomes are relatively small, typically -40 kb in yeast or flies and -100 kb in animal cells.