DNA-PK, ATM, and ATR phosphorylate a variant histone H2AX within the chromatin near the damage site & Phosphorylated H2AX acts as a landing pad for recruiting additional protein complexes that control DNA repair

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#Id: 9654

#Unit 4. Cell Communication and Cell Signaling

Feedback regulation by MAP Kinase

activated MAP kinase phosphorylates the HER1 on a threonine residue near the juxtamembrane domain. 

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Feedback regulation by MAP Kinase

Phosphorylation of threonine residue in HER1 decreases the ability of the receptor kinase to become fully active.

TLS Online TPP Program

#Id: 9656

#Unit 4. Cell Communication and Cell Signaling

Feedback regulation by MAP Kinase

Active MAP kinase phosphorylates Raf on multiple sites, reducing its association with Ras.

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#Unit 4. Cell Communication and Cell Signaling

Negative feedback regulation by MAP Kinase

activated MAP kinase triggers an increase in the expression of dual-specificity phosphatases (DUSPs), particularly DUSP6.

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#Unit 4. Cell Communication and Cell Signaling

Hormonal stimulation of GPCR leads to the activation of PLC (IP3/DAG pathway).

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#Unit 4. Cell Communication and Cell Signaling

GPCRs specifically activate the β isoform of PLC (PLCβ)