TLS Online TPP Program

#Id: 3708

#Unit 2. Cellular Organization

Different thalassemias are caused by various deletions that eliminate a- or b-globin genes. The severity of the disease depends on the individual deletion.

TLS Online TPP Program

#Id: 3709

#Unit 2. Cellular Organization

Depending on the diploid combination of thalassemic alleles, an affected individual may have any number of a chains from zero to three.

TLS Online TPP Program

#Id: 3710

#Unit 2. Cellular Organization

if an individual has only one a gene, the excess b chains form the unusual tetramer b4, which causes hemoglobin H (HbH) disease. The complete absence of a genes results in hydrops fetalis, which is fatal at or before birth.

TLS Online TPP Program

#Id: 3711

#Unit 2. Cellular Organization

Hb anti-Lepore, Hb Kenya result from unequal crossing over between linked genes

TLS Online TPP Program

#Id: 3712

#Unit 2. Cellular Organization

Ribosomal RNA is encoded by a large number of identical genes that are tandemly repeated to form one or more clusters called as rDNA cluster

TLS Online TPP Program

#Id: 3713

#Unit 2. Cellular Organization

Part of genome which changes expression of genome called as mutable loci or sometimes GENES