The SH2 domain binds strongly to short target peptides containing a critical four-residue core sequence:: 

phosphotyrosine–glutamic acid–glutamic acid–isoleucine

TLS Online TPP Program

#Id: 4570

#Unit 8. Inheritance Biology

TLS Online TPP Program

#Id: 8380

#Unit 2. Cellular Organization

single head domain

Function- Membrane association, endocytosis

TLS Online TPP Program

#Id: 8852

#Unit 2. Cellular Organization

Geminin contains a destruction box at its N-terminus that is recognized by APC/Ccdh1, causing it to be ubiquitinylated in late anaphase and degraded by proteasomes.

TLS Online TPP Program

#Id: 7241

#Unit 5. Developmental Biology

Formation of mature B-cell

TLS Online TPP Program

#Id: 10022

#Unit 4. Cell Communication and Cell Signaling

Dissociation of cytosolic complex leads to the stabilization of the full-length Ci, which moves into the

nucleus, displaces the repressor Ci75 from the promoter of target genes, and induces expression of target genes.