TLS Online TPP Program

#Id: 10411

#Unit 4. Cell Communication and Cell Signaling

Warburg effect

The production of lactate in the presence of oxygen is called aerobic glycolysis

TLS Online TPP Program

#Id: 10412

#Unit 4. Cell Communication and Cell Signaling

Cancer- specific metabolite

2-Hydroxyglutarate produce by mutated IDH

TLS Online TPP Program

#Id: 10413

#Unit 4. Cell Communication and Cell Signaling

Angiogenesis

The developmental process for the formation of blood vessels that are needed to supply nutrients to a growing tumor

TLS Online TPP Program

#Id: 10414

#Unit 4. Cell Communication and Cell Signaling

Growth factors that stimulate angiogenesis:

Basic fibroblast growth factor, TGF-α, and VEGF

TLS Online TPP Program

#Id: 10415

#Unit 4. Cell Communication and Cell Signaling

Hypoxia-inducible factor 1 (HIF-1) induces transcription of the VEGF gene

TLS Online TPP Program

#Id: 10416

#Unit 4. Cell Communication and Cell Signaling

Prolyl hydroxylase 

active at normal O2 levels, Hydroxylation of HIF-1 causes ubiquitinylation and degradation