Following binding of an EGF ligand, the rate of endocytosis of HER1 is increased about tenfold, and only a fraction of the internalized receptors return to the plasma membrane; the rest are degraded in lysosomes.

TLS Online TPP Program

#Id: 10458

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10459

#Unit 4. Cell Communication and Cell Signaling

Inappropriate production of nuclear transcription factors such as FOS, JUN, and MYC can induce transformation.

TLS Online TPP Program

#Id: 10460

#Unit 4. Cell Communication and Cell Signaling

Burkitt’s lymphoma

translocation between chromosomes 8 and 14

TLS Online TPP Program

#Id: 10461

#Unit 4. Cell Communication and Cell Signaling

In Burkitt’s lymphoma cells, 

MYC is translocated close to an antibody gene, leading to overproduction of MYC

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#Id: 10462

#Unit 4. Cell Communication and Cell Signaling

MYC gene encodes a basic helix-loop-helix protein

include MAD, MAX, and MNT

TLS Online TPP Program

#Id: 10463

#Unit 4. Cell Communication and Cell Signaling

MYC-MAX dimers regulate genes that control proliferation, such as cyclins.