Fus3 equivalent to MAP kinase

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#Unit 4. Cell Communication and Cell Signaling

Maximal activation of PKB depends on recruitment to the cytosolic surface of the plasma membrane of two other kinases -PDK1 and PDK2.

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#Unit 4. Cell Communication and Cell Signaling

PDK1 can phosphorylate PKB on a critical threonine residue in its activation loop

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#Unit 4. Cell Communication and Cell Signaling

Phosphorylation by the mTORC2 kinase complex, of a second serine on

PKB that is not in the activation loop is necessary for maximal PKB activity

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#Unit 4. Cell Communication and Cell Signaling

Activated PKB directly phosphorylates and inactivates a protein Bad

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#Unit 4. Cell Communication and Cell Signaling

Activated PKB also promotes survival of many cultured cells by phosphorylating the Forkhead transcription factor FOXO3a on multiple serine and threonine residues.

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#Unit 4. Cell Communication and Cell Signaling

The cytosolic phosphoserine binding protein 14-3-3 then binds to phosphorylated FOXO3a and sequesters it in the cytosol.