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TLS Online TPP Program

#Id: 9982

Frizzled receptor possesses a unique hydrophobic cleft adapted to interact with lipidated Wnts, a binding conformation mimicked in Notum’s structure as well.

#Unit 4. Cell Communication and Cell Signaling #Wnt Signaling #Part B Pointers
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TLS Online TPP Program

#Id: 8518

#Unit 2. Cellular Organization

Defects in LIS1 
Miller-Dieker lissencephaly
means “smooth brain”
TLS Online TPP Program

#Id: 8519

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8520

#Unit 2. Cellular Organization

Post-translational modifications of tubulin:
Lysine acetylation
Detyrosylation
Polyglutamylation
Polyglycylation
TLS Online TPP Program

#Id: 8521

#Unit 2. Cellular Organization

Lysine acetylation & Detyrosylation are found only on α-tubulin and are absent from β-tubulin.
TLS Online TPP Program

#Id: 8522

#Unit 2. Cellular Organization

Lysine acetylation 
ε-amino group of a specific lysine of α-tubulin
Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)
TLS Online TPP Program

#Id: 8523

#Unit 2. Cellular Organization