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TLS Online TPP Program

#Question id: 1251

 Following statements are regarding to receptor serine kinases.

A. The two serines in each Smad3 that were phosphorylated by the RI receptor kinase bind to phosphoserine-binding sites in the MH1 domains of a Smad3 or a Smad4, forming a stable complex containing two molecules of phosphorylated Smad3 (or Smad2) and one molecule of the co-Smad (Smad4).

B. The bound importin then mediates translocation of the heteromeric R-Smad/co-Smad complex into the nucleus.

C. After importin dissociates inside the nucleus, the Smad3/Smad4 (or Smad2/Smad4) complex binds to other transcription factors to activate transcription of specific target genes.

D. Transcription of the PAI-1 gene requires formation of a complex of the transcription factor TFE3 with the R-Smad/co-Smad (Smad3/Smad4) complex and binding of all these proteins to specific sequences within the regulatory region of the PAI-1 gene.

E. Within the nucleus, R-Smads are further modified by phosphorylation of their linker domains, monoubiquitinylation of their MH1 domains, acetylation of their MH2 domains, and dephosphorylation of the C-terminal serines by nuclear phosphatases.

Which of the following combination is incorrect?

#Unit 4. Cell Communication and Cell Signaling

  1. A, B and E

  2. C and D

  3. A and E

  4. B only

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TLS Online TPP Program

#Question id: 14838

#Unit 5. Developmental Biology

Sequence of amphibian lens induction postulated by experiments on embryos of the frog Xenopus laevis ; EXCEPT
TLS Online TPP Program

#Question id: 14839

#Unit 5. Developmental Biology

Given are certain facts which define ‘specification’ of a developing embryo.
 A. At the specification stage, commitment to cell identity is labile.
 B. At the specification stage, cell is capable of differentiating autonomously.
 C. The cell “knows” very early what it is to become without interacting with other cells.
 D. A phase where inductive signals trigger cell to determines their fate.
 Which of the above statements best define specification?
TLS Online TPP Program

#Question id: 14840

#Unit 5. Developmental Biology

If a cell or tissue type is able to differentiate according to its specified fate, it is assumed that commitment is:
TLS Online TPP Program

#Question id: 14841

#Unit 5. Developmental Biology

How cells became different from one another during embryonic development?
TLS Online TPP Program

#Question id: 14842

#Unit 5. Developmental Biology

If a specified cell is transplanted to a population of differently specified cells, the fate of the transplant will be:
A. Altered if the specification is reversible
B. Capable of differentiating by itself if the specification is reversible
C. Altered if the specification is irreversible
D. Capable of differentiating by itself if the specification is irreversible
Which of the following combination is correct?
TLS Online TPP Program

#Question id: 14843

#Unit 5. Developmental Biology

In both animals and plants, undifferentiated cells go through a process of maturation that begins when they become committed to a specific cell lineage.
   
Which of the following option represents correct events regarding to series