Practice Questions

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#Question id: 16140

Many mouse genes are “tissue-specific,” that is, they are present throughout the body but are expressed in only one of the animal’s many tissue types. (Other mouse genes are expressed throughout the body, or in multiple tissues.) Geneticists can study the regulation of a mouse gene by fusing the gene’s promoter region to the LacZ coding sequence and injecting the construct to create a transgenic mouse. Fusion of the mouse amylase promoter to LacZ yielded a Pamylase-LacZ construct.
You are surprised to observe that mice homozygous for the transgene insertion display a serious heart defect. (Heterozygotes have normal hearts.) which one is a possible explanation?
a) LacZ overexpression (with two copies of the transgene) causes the defect.
b) the insertion disrupted a gene that is haploinsufficient.
c) the insertion disrupted a gene that is haplosufficient.
d) LacZ expression inhibition (with two copies of the transgene) causes the defect.
Which of the following statements is correct predict about the heart defect?

#Unit 13. Methods in Biology

More Questions

#Question id: 27412

#Unit 1. Molecules and their Interaction Relevant to Biology

Choose the correct

1. Mutation in B-galactosidase leads to the deposition of GM1 causes Generalized gangliosidosis

2. Mutation in hexosaminidase leads to the deposition of GM2 causes Tay-Sachs

3. Mutation in glucocerebrosidase leads to the deposition of Glc causes Gaucher disease

4. Mutation in sphingomyelinase leads to the deposition of Phosphocholine causes Niemann-Pick disease

#Question id: 27413

#Unit 1. Molecules and their Interaction Relevant to Biology

Sandhoff disease are related to the mutation in which of the following enzyme

#Question id: 27414

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correctly describing the common structure of any sterol

#Question id: 27415

#Unit 1. Molecules and their Interaction Relevant to Biology

#Question id: 27416

#Unit 1. Molecules and their Interaction Relevant to Biology

#Question id: 27417

#Unit 1. Molecules and their Interaction Relevant to Biology