TLS Online TPP Program

#Question id: 2873


With reference to aberrant methylation of bases which of the following statements, if any, is false?

#Unit 2. Cellular Organization
  1. S-adenosylmethionine donates methyl groups to a range of different molecules in cells and frequently inappropriately methylates bases in DNA.

  2. Guanine is occasionally methylated to give O-6-methylguanine which base pairs with adenine rather than with cytidine.

  3. In each nucleated cell, about 300-600 adenines are converted to 3-methyladenine per day.

  4.  3-methyladenine can be a cytotoxic base: it distorts the double helix and that can disrupt crucial DNA-protein interactions.